I looked though the Sync 3 shop manual (415-00B), The only microphone listed is labeled "Voice Microphone". The description says it's for voice commands and hands free calling so I think It's safe to say there is no ANC (Active Noise Cancellation) like the Mustang has. The manual can be found...
Metra just announced two dash kits for installing aftermarket head units in the Ranger with the 4.2" screen. One for single or double DIN and one specifically for the Pioneer DMH-C5500NEX. They are on display at CES this week. I Didn't see any info on pricing or when they will be available...